Experimental and Theoretical NANOTECHNOLOGY (ETN) abbreviated as Exp. Theo. NANOTECHNOLOGY is a multidisciplinary peer-reviewed and open access journal. It includes specialized research papers, short communications, reviews and selected conference papers in special issues on the characterization, synthesis, processing, structure and properties of different principles and applications of nanotechnology with focus on advantageous achievements and applications for the specialists in engineering, chemistry, physics, materials science and medicine. ETN covers and publishes all aspects of fundamental and applied researches of experimental and theoretical nanoscale technology dealing with materials synthesis, processing, nanofabrication, nanoprobes, spectroscopy, properties, biological systems, nanostructures, nanoelectronics, nano-optics, nano-mechanics, nanodevices, nanobiotechnology, nanomedicine, nanotoxicology within the scope of the journal. ETN aims to acquire the recent and outstanding researches for the benefit of the human being.
Solid phase microextraction based micro-device for extraction of PCR amplifiable DNA
Deoxyribonucleic acid (DNA) extraction or sample preparation from biological sample (whole blood) for downstream process on microfluidic platform has been widely studied due to its crucial role in clinical diagnostic and genetic analysis. Sample preparation can be complicated since blood comprises complex matrices and repeated blood pricking from patients can be affected their health. Thus, introduction of solid-phase microextraction (SPME) method would be suitable to isolate, fractionate and concentrate the analyte from complex sample matrices and implemented on microfluidic device with small amount of sample. SPME is an effective sample preparation method by chemical lysis followed by purification mostly by using silica-based platform developed based on direct absorption into silica resins and desorption of analyte from silica resins.
Keywords: Extraction; Whole blood; Micro-device.