Experimental and Theoretical NANOTECHNOLOGY (ETN) abbreviated as Exp. Theo. NANOTECHNOLOGY is a multidisciplinary peer-reviewed and open access journal. It includes specialized research papers, short communications, reviews and selected conference papers in special issues on the characterization, synthesis, processing, structure and properties of different principles and applications of nanotechnology with focus on advantageous achievements and applications for the specialists in engineering, chemistry, physics, materials science and medicine. ETN covers and publishes all aspects of fundamental and applied researches of experimental and theoretical nanoscale technology dealing with materials synthesis, processing, nanofabrication, nanoprobes, spectroscopy, properties, biological systems, nanostructures, nanoelectronics, nano-optics, nano-mechanics, nanodevices, nanobiotechnology, nanomedicine, nanotoxicology within the scope of the journal. ETN aims to acquire the recent and outstanding researches for the benefit of the human being.
The purpose of this study was to enhance the therapeutic effect of magnesium orotate )MO( via loading it to gum arabic nanocarrier. The magnesium orotate-loaded gum arabic nanoparticles )MOGANPs( were prepared by high pressure homogenizer. The freeze-dried powder of nanoparticles was characterized using X-ray Diffractometry )XRD( and Transmission Electron Microscopy )TEM(. The obtained nanoparticles were spherical in shape with diameters ranged from 30 to 50 nm. The cytotoxicity of MOGANPs was determined against human hepatocellular carcinoma HepG2 cell line using 3-)4,5-dimethylthiazol-2-yl (2,5-diphenyl tetrazolium bromide )MTT( assay which showed an enhanced efficacy of MO nano-carried with gum arabic when compared to pure compound alone. Moreover, the results revealed that MOGANPs induced apoptosis in the treated HepG2 cells and thus it is promising formulation, in addition, further anticancer studies are needed.
Keywords: Magnesium orotate; Gum; Liver cancer; Cytotoxicity.